im taking 5000 mcg of b12 . Good luck VCL We aimed to elucidate the role of vitamin B12 in lung cancer etiology via direct measurements of pre-diagnostic circulating vitamin B12 concentrations in a nested case–control study, complemented with a Mendelian randomization (MR) approach in an independent case–control sample. And indeed, nearly three-quarters of cancer patients exhibit elevated B12 levels. Elevated plasma vitamin B12 levels and cancer prognosis: A population-based cohort study. But did do vitamin IV's For years. Carcinomas most frequently involved are HCC and metastatic colon, breast and pancreatic cancer. And, if you remember, reverse causation is when instead of X leading to Y, maybe Y is instead leading to X. Dr. Gurmukh Singh answered 49 years experience Pathology Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels of cobalamin. High vitamin B12 and cancer Association between elevated B12 and cancer first described in 1975 by Carmel et al. High B-12 levels may indicate liver disease, diabetes, or another condition. Some people who take suppliments go much higher ...very very high. ... stomach cancer high red blood cell count... and more than 60 others. J Natl Cancer Inst 2013;105:(23):1799-805. Moreover, in this study, the prevalence of vitamin B 12 deficiency among metastatic solid tumor cancer (except gastric) patients was 0.8% (4/527 patients), while 41.9% (221/527 patients) of the patients had high vitamin B 12 levels, which shows that, in particular, elevation of vitamin B 12 is frequently observed in metastatic cancer patients. However, it is extremely rare to have a high blood level from too much vitamin B12 in the diet. Vitamin B12 is an essential nutrient, useful for maintaining blood and nerve health, and can be found in foods like sardines and eggs.. since beginning this my serum level went from 500 to >2000, is the supplement the cause? Paper III. vitamin B12 The information provided herein should not be used for diagnosis or treatment of any medical condition. However, the implications for early cancer detection in primary care have not been assessed. And maybe stored in the liver that could raise levels. Over-production of Vitamin B12 can be caused by cirrhosis, hepatitis, polycythemia vera or myelocytic leukemia. The vitamin b12 elevation can be influenced by supplements And foods And fortified cereals. However, the cancer risk among patients with newly diagnosed high Cbl levels has not been adequately examined. Background: A substantial proportion of patients referred for plasma vitamin B12 (cobalamin [Cbl]) measurement present with high Cbl levels, which have been reported in patients with different cancer types. These also determine how well your detox system is working. The authors conclude that the originally high B12 levels were indicative of undiagnosed cancer (Arendt, 2019). Hi Ashweb901 I read (or miss-read) it the other way round - having low levels of B12 and B9 may increase the risk of BC - but then I'm not a medically trained person. So, instead of high B12 blood levels leading to cancer, maybe cancer leads to high blood levels. Vitamin B12 levels of at least 550 but less than 650 pg/mL are associated with a 26% increased mortality risk vs. levels below 400 pg/mL. The lower levels of vitamin B12 in serum are often used to assess the state of the vitamin, but this approach generates a high rate of false-negative results. INTRODUCTION: Both venous thromboembolism (VTE) and high plasma vitamin B12 levels (cobalamin, Cbl) are markers of occult cancer and aggressive cancer with a poor prognosis. tion between high serum vitamin B12 levels, or hyp-ercobalaminemia (HCbl), and solid tumors. HCbl in solid tumors is related to an excess synthesis of transcobalamins by the tumor or an increase in haptocorrin secondary to hyperleukocytosis [6–8]. I take no suppliments. There are cases where an individual has an elevated vitamin B12 level that is seen as an incidental finding in someone who has not recently received a vitamin B12 injection or taken a vitamin B12 supplement. Now mine is getting lower in the 800's. Background A substantial proportion of patients referred for plasma vitamin B12 (cobalamin [Cbl]) measurement present with high Cbl levels, which have been reported in patients with different cancer types. Why is a vitamin B-12 level test useful? Causes of vitamin B12 deficiency include: Not enough vitamin B12 in diet (rare, except with a strict vegetarian diet) Diseases that cause malabsorption (for example, celiac disease and Crohn disease) Lack of intrinsic factor, a protein that helps the intestine absorb vitamin B12 Folic Acid, B12, and Lung Cancer Ebbing and colleagues analyzed data from two studies that included almost 7,000 heart patients treated with B vitamin … A large-scale study looked at 5,000 lung cancer-control pairs and reviewed genetic data of 29k cancer … However, the cancer risk among patients with newly diagnosed high Cbl levels has not been adequately examined. Finding the true cause means ruling out or confirming each possibility – in other words, diagnosis. Yet, Carmel et al. They looked at circulating vitamin B12 (cobalamin) levels in around 25,000 subjects one year prior to a cancer diagnosis, and compared these with about 60,000 cancer patients for whom blood cobalamin hadn’t been measured. Methods: We conducted this cohort study using population-based Danish … Background: Elevated vitamin B12 levels (B12) are associated with increased short-term cancer risk. By lowering homocysteine levels, it may also protect against cardiovascular disease. The high frequency of high serum cobalamin was recently exemplified in a retrospective study by Deneuville et al., which included 3702 hospitalized patients in whom high levels of vitamin B12 were found in 12% of cases, whereas a deficiency was only observed in 10% of cases. in 1977 reported a significant association between high serum vitamin B12 levels, or hypercobalaminemia (HCbl), and solid tumors. Similarly, in over 476,000 people without cancer or vitamin B12 prescriptions (injections), high B12 levels (> 1,200 pmol/L) were linked to a higher incidence of cancer . This article attempts to draw mortality conclusions from 10-year old single B12 level determinations without corrections for the often fatal diseases associated with high levels; high levels demand a careful work up, and should not be attributed to OTC supplementation. The methylfolate is what converts serum blood b-12 to cellular usable b12. TUESDAY, Aug. 22, 2017 (HealthDay News) -- Men, and especially male smokers, appear to be more likely to develop lung cancer if they take high doses of vitamins B6 and B12… To assess high Cbl levels and risk of cancer, Arendt and his colleagues used Danish Medical registries to review the records of 333,667 patients without cancer who had been referred for Cbl testing. By Carmel et al now mine is getting lower in the diet against! Also protect against cardiovascular disease % of patients with high B12 blood levels leading to X elevated plasma B12... 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