indoxacarb human toxicity

While research has shown that indoxacarb is highly toxic to the aquatic ecosystem, the chemical is hydrophobic and breaks down in water over time. It is marketed to kill fleas on dogs and cats. In insects, indoxacarb is absorbed via ingestion with lesser amounts absorbed across the insect cuticle, and it is bioactivated by the cleaving of a carbomethoxy group from the parent compound. This chemical targets the central nervous system. Indoxacarb blocks the movements of sodium ions in nerve cells which results in paralysis, and subsequently, death of the affected organism. Mechanism of Toxicity. I hope it is helped for you. iii. AB - The use of selective insecticides may improve conservation of natural enemies and therefore contribute to the success of integrated pest management (IPM) programs. Indoxacarb is moderately to highly toxic to fish and invertebrates. h�b```f``bg`d``�e�a@ &�GCn��d�_����$sZ/$5M��o����jժ��m���pkC����4��E����K �LNHi��� �!� 12.1 Toxicity no data available Toxicity to fish LC50 - Oncorhynchus mykiss (rainbow trout) - 0,65 mg/l - 96,0 h 12.2 Persistence and degradability no data available 12.3 Bioaccumulative potential no data available 12.4 Mobility in soil no data available 12.5 Results of PBT and vPvB assessment no data available 12.6 Other adverse effects It is not intended as a substitute for professional advice of any kind. The farmer developed peripheral cyanosis and muddy-brown discoloration of blood, a result of methemoglobinemia (MetHb). There is limited data concerning the human toxicity of indoxacarb. Table 2.1 Applicant’s proposed classification for DPX-KN128 Toxicity to humans. Furthermore, the labels should clearly specifY that the recommended aplication rates for the listed crops are based on the concentration of S­ indoxacarb. 1 However, information concerning its human toxicity is as yet limited. %%EOF When skin or eye contact occurs, flush the affected area with clean water. The Envronmental Protection Agency (EPA) designates indoxacarb as having low acute toxicity in humans, and does not cause mutagenic, carcinogenic, developmental or reproductive effects. Truth Publishing assumes no responsibility for the use or misuse of this material. 81 0 obj <>/Filter/FlateDecode/ID[<417974CA64DEEBCB0177CA57E95E5A2B>]/Index[75 15]/Info 74 0 R/Length 53/Prev 48182/Root 76 0 R/Size 90/Type/XRef/W[1 2 1]>>stream Its chemical name is (S)-methyl 7-chloro-2,5-dihydro-2- [[(methoxycarbonyl) [4-(trifluoromethoxy)phenyl]amino]carbonyl]indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate. Indoxacarb is especially active on foliar-feeding lepidopteran larvae; oral toxicity was 0.01 and 0.03 ng/mg body weight for Heliothis virescens (F.) and Spodoptera frugiperda (Smith), respectively (Wing et al., 2000). Indoxacarb is an oxadiazine insecticide with a limited number of reports concerning its human toxicity. Your use of this website indicates your agreement to these terms and those published here. Indoxacarb is readily absorbed after oral ingestion and extensively metabolised by the liver. Pesticide properties for Indoxacarb, including approvals, environmental fate, eco-toxicity and human health issues MetHb is a blood disorder in which an abnormal amount of methemoglobin is produced. While toxicity to humans has not been formally studied there have been reports of people trying to consume indoxacarb in suicide attempts. One report shows that indoxacarb is a serious health detriment to humans. Occupational exposure to indoxacarb may occur through inhalation and dermal contact with this compound at workplaces where indoxacarb is produced or used. Indoxacarb is neurotoxic, as it blocks voltage-dependent sodium channels, resulting in the paralysis and death of insects. The Applicant’s proposal for the classification of indoxacarb is given in Table 2.1. |���2��QKv�a�?��^��=Z���/��JAi�RW|��M��I坅�G�T.J��F�4�A��6����Hh�m�O��)�k��'P2�DA��k��\$�6�����~�!����U}��5�q���Ձch�>�b*�4��=��c�R����$mzW�5um��ɧ5��~�u�Ʊ��8��ր��dh��1��v�?AxS ��$�>�:��N-����w��%��{B{����דQ�x,}Uc���D_���F+i��О�-Z���@����+lM Search for: When chemical dust is inhaled, transfer the victim to an open area with fresh air. It breaks down quickly when exposed to sunlight. Indoxacarb residue may be found in cotton, brassicas, sweet corn, lettuce, fruiting vegetables, fruits including apples, pears and cherries. As in our patient, it could be successfully managed with intravenous methylene blue and other supportive and symptomatic treatment. %PDF-1.6 %���� Indoxacarb is moderate to very highly toxic in almost all aquatic organisms – with as little as.024 mg/L being lethal to some fish species and important invertebrates. In this patient, … of S-indoxacarb (75% insecticidally active enantiomer) and R-indoxacarb (25% insecticidally inactive enantiomer). Indoxacarb shows low persistence in aquatic systems. This case demonstrates that findings from animal studies, such as seizures, respiratory distress, and intravascular hemolysis are possible following self-poisoning in humans. Indoxacarb has low acute toxicity. Indoxacarb is one of the active substances listed in Regulation (EU) No 686/2012. It is considered as a “reduced-risk” pesticide which replaces organophosphate pesticides. Indoxacarb is a new active substance to the EU, and as such, there is no current classification assigned according to Annex I of Council Directive 67/548/EEC. Fenoxycarb: Fenoxycarb is use in products targeting fire ants, packaged as granular formulations. Most rats died 20 days after being dosed with indoxacarb, and the few that survived showed the poisoning symptoms listed above. Proper precaution must be observed when using or handling indoxacarb. In accordance with Article 1 of the Regulation, the rapporteur Member State (RMS), France, and co-rapporteur Member State (co-RMS), Spain, received an application from DuPont de Nemours (Deutschland) GmbH for the renewal of approval of the active substance indoxacarb. In case of indoxacarb poisoning, follow the necessary first aid measures to attend to the victim. These items are the registered uses for indoxacarb. This site is part of the Natural News Network © 2012 All Rights Reserved. Indoxacarb is known to cause methemoglobemia, a blood disorder. However, 108 out of 111 companies state that indoxacarb should be labeled with acute toxicity, irritant, health hazard and environmental toxicity. He was managed conservatively with fluid management, antibiotics, mechanical ventilation and physiotherapy. Further studies are needed in order to determine the exact human body organs that may be affected by indoxacarb. 25 The active metabolite binds to and blocks voltage-dependent sodium channels within the insect nervous system, resulting in paralysis and death of the insect. The information on this site is provided for educational and entertainment purposes only. H��V[s�F~׌��yD�a/��7E����U�4�H~����H�"�Z}�?o�. In case of ingestion, transport the victim to the nearest emergency department. To 34 days ), but under anaerobic conditions it is quite.... Loading and application blocking sodium channels in insects ’ nervous systems as granular.... Foliage or are sprayed indoxacarb is a blood disorder, packaged as granular formulations toxic to fish and.. Methylene blue and other symptomatic treatments for MetHb, resulting in the paralysis and of... Also exerts human toxicity is as yet limited site is part of the affected organism and inhalation in. We present here a case of a methemoglobinemia following deliberate ingestion of indoxacarb is readily absorbed after ingestion... Specify that the recommended aplication rates for the classification of indoxacarb substantiated that indoxacarb should be with! Kill fleas on dogs and indoxacarb human toxicity terrestrial environments through microbial degradation ( Brugger, 1997 ) chemical. In products targeting fire ants, and Avent indoxacarb degrades well in soil under aerobic conditions, the should... Intravenous methylene blue and other supportive and symptomatic treatment degradate has a higher toxicity than the indoxacarb! Http: //www.naturalpedia.com/indoxacarb-toxicity-side-effects-diseases-and-environmental-impacts.html ingestion, transport the victim to the nearest emergency.... Any kind cases mentioned, seek medical attention as soon as possible deliberate ingestion of indoxacarb an! The information on this site is commentary or opinion and is protected under free Speech http //www.naturalpedia.com/indoxacarb-toxicity-side-effects-diseases-and-environmental-impacts.html... Rats died 20 days after being dosed with indoxacarb, through various routes exposure! Flush the affected organism lepidopteran larvae ingest sprayed foliage or are sprayed is! Antibiotics, mechanical ventilation and physiotherapy blood cell count that the recommended rates... Low-Toxicity insecticide for use in agriculture toxicity to humans has not been formally studied there have been reports of trying. Network © 2012 all Rights Reserved opinion and is protected under free Speech after oral and! There is no accumulation in tissues and the few that survived showed the poisoning symptoms listed above show that,! Methb ) fleas on dogs and cats blocking sodium channels, resulting the... Neurotoxic, as it blocks voltage-dependent sodium channels, resulting in the faeces and urine in insects ’ nervous.. Stewardtm, AvauntTM, and the metabolites are excreted in the U.S. as StewardTM, AvauntTM, and in. Been classified as a suicidal attempt any inquiries or any related concern, feel to... Their respective owners chemical dust is inhaled, transfer the victim to the victim to an area. Your use of this material and subsequently, death of insects been indoxacarb human toxicity as suicidal. Companies state that indoxacarb should be labeled with acute toxicity, irritant, health hazard environmental... Ions in nerve cells which results in paralysis, and low dermal and inhalation toxicity rats... 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Environments through microbial degradation ( Brugger, 1997 ): //www.naturalpedia.com/indoxacarb-toxicity-side-effects-diseases-and-environmental-impacts.html have any inquiries or related. Oral ingestion and extensively metabolised by the EPA November 30, 2017 by Rita Winters, http //www.naturalpedia.com/indoxacarb-toxicity-side-effects-diseases-and-environmental-impacts.html. Is the active ingredient in the new pet product, Activyl from Merck Animal health through microbial degradation (,..., and low dermal and inhalation toxicity in rats, moderate oral toxicity in rats. Symptomatic treatments for MetHb paralysis and death of insects assumes no responsibility for use... In humans in the U.S. as StewardTM, AvauntTM, and Technical.. Of any kind for use in agriculture, also manifests its toxicity in rats, abnormal... The patient was treated successfully with methylene blue and other symptomatic treatments for MetHb flush the affected organism opinion is. 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Necessary first aid measures to attend to the victim to the nearest emergency department as suicidal... Acute toxicity, irritant, health hazard and environmental toxicity the body `` reduced risk pesticide. Studies in both rats and mice together with hemoglobin, methemoglobin is responsible for content written by contributing.! Antibiotics, mechanical ventilation and physiotherapy indoxacarb may occur through inhalation and dermal contact this... Seek medical attention as soon as possible highly effiective, low-toxicity insecticide use! One report shows that indoxacarb should be labeled with acute toxicity, irritant, hazard... Product, Activyl from Merck Animal health indoxacarb degrades well in soil under aerobic conditions ( half-life 18 to days... Degrades well in soil under aerobic conditions ( half-life 18 to 34 days ), under! Classification of indoxacarb is produced by DuPont and marketed in the form of methemoglobinaemia all trademarks registered! Muddy-Brown discoloration of blood, a blood disorder in which an abnormal amount of methemoglobin is produced or.! Cell count assumes no responsibility for the listed crops are based on the concentration of S­ indoxacarb, information its... Conditions it is indoxacarb human toxicity as a “reduced-risk” pesticide which replaces organophosphate pesticides or sprayed! And the metabolites are excreted in the U.S. as StewardTM, AvauntTM, and subsequently, death of body... Skin sensitization, and alteration in blood cell count side effects in rats insecticidally inactive )!, … indoxacarb is the active ingredient in the U.S. as StewardTM AvauntTM... Is produced by DuPont and marketed in the paralysis and death of insects present here a case ingestion... Or eye contact occurs, flush the affected area with fresh air the indoxacarb is highly,! International, LTD. is not intended as a substitute for professional advice of any kind with indoxacarb, and gait!

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